Steps in a typical equivalence data analysis

Steve Simon


There are three approaches that are used to demonstrate equivalence, each with its advantages and disadvantages.

  1. Establish adequate power
  2. Report confidence intervals
  3. Perform two one-sided tests

Each of these approaches requires that you define a range of clinical indifference first.

Defining a range of clinical indifference

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Establishing adequate power

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Reporting confidence intervals

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Performing two one-sided tests

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Modifications for non-inferiority trials

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You can find an earlier version of this page on my original website.