Recommendation: The Empirical Evidence of Bias in Trials Measuring Treatment Differences

Steve Simon


Categories: Recommendation Tags: Critical appraisal Randomization

When I wrote a book about Evidence Based Medicine back in 2006

selection bias through randomization (sequence generation and allocation concealment); confounding through design or analysis; performance bias through fidelity to the protocol

The general finding was that failure to use these bias reduction approaches tended to exaggerate treatment effects

Nancy D Berkman