Proving the null hypothesis in clinical trials

Steve Simon

2017-04-27

Figure 1. First page of research article

I’m attending a great short course on non-inferiority trials and the speaker provided a key reference of historical interest. This reference is the one that got the Statistics community interested in the concept of non-inferiority. The full text is behind a paywall, but you can look at the abstract. A footnote is a paper, Dunnett and Gent 1977, (also trapped behind a paywall) addressed this problem earlier.

Blackwelder WC. “Proving the null hypothesis” in clinical trials. Control Clin Trials. 1982 Dec;3(4):345-53. Article is bheind a pay wall.

You can find an earlier version of this page on my blog.